Middle East Respiratory Syndrome Coronavirus “MERS-CoV”: Current Knowledge Gaps
Identifieur interne : 001686 ( Main/Exploration ); précédent : 001685; suivant : 001687Middle East Respiratory Syndrome Coronavirus “MERS-CoV”: Current Knowledge Gaps
Auteurs : G. R. Banik [Australie] ; G. Khandaker [Australie] ; H. Rashid [Australie]Source :
- Paediatric Respiratory Reviews [ 1526-0542 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (virologie), Maladies de l'appareil respiratoire (), Maladies de l'appareil respiratoire (diagnostic), Maladies de l'appareil respiratoire (virologie), Mâle, Voyage.
- MESH :
- diagnostic : Infections à coronavirus, Maladies de l'appareil respiratoire.
- virologie : Infections à coronavirus, Maladies de l'appareil respiratoire.
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Femelle, Humains, Infections à coronavirus, Maladies de l'appareil respiratoire, Mâle, Voyage.
English descriptors
- KwdEn :
- Animals, Coronavirus Infections (diagnosis), Coronavirus Infections (therapy), Coronavirus Infections (virology), Female, Humans, Male, Middle East Respiratory Syndrome Coronavirus, Respiratory Tract Diseases (diagnosis), Respiratory Tract Diseases (therapy), Respiratory Tract Diseases (virology), Travel.
- MESH :
- diagnosis : Coronavirus Infections, Respiratory Tract Diseases.
- therapy : Coronavirus Infections, Respiratory Tract Diseases.
- virology : Coronavirus Infections, Respiratory Tract Diseases.
- Animals, Female, Humans, Male, Middle East Respiratory Syndrome Coronavirus, Travel.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) that causes a severe lower respiratory tract infection in humans is now considered a pandemic threat to the Gulf region. Since its discovery in 2012, MERS-CoV has reached 23 countries affecting about 1100 people, including a dozen children, and claiming over 400 lives. Compared to SARS (severe acute respiratory syndrome), MERS-CoV appears to kill more people (40% versus 10%), more quickly, and is especially more severe in those with pre-existing medical conditions. Most MERS-CoV cases (>85%) reported thus far have a history of residence in, or travel to the Middle East. The current epidemiology is characterised by slow and sustained transmission with occasional sparks. The dromedary camel is the intermediate host of MERS-CoV, but the transmission cycle is not fully understood. In this current review, we have briefly summarised the latest information on the epidemiology, clinical features, diagnosis, treatment and prevention of MERS-CoV especially highlighting the knowledge gaps in its transmission dynamics, diagnosis and preventive strategy.
Url:
DOI: 10.1016/j.prrv.2015.04.002
PubMed: 26002405
PubMed Central: 7106011
Affiliations:
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Le document en format XML
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R." last="Banik">G. R. Banik</name><affiliation wicri:level="1"><nlm:aff id="aff0005">National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">University of Technology Sydney, School of Medical and Molecular Biosciences, Broadway, Sydney, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Technology Sydney, School of Medical and Molecular Biosciences, Broadway, Sydney, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Khandaker, G" sort="Khandaker, G" uniqKey="Khandaker G" first="G." last="Khandaker">G. Khandaker</name><affiliation wicri:level="1"><nlm:aff id="aff0005">National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0015">Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0020">Centre for Perinatal Infection Research, The Children's Hospital at Westmead and The University of Sydney, Sydney, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Perinatal Infection Research, The Children's Hospital at Westmead and The University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0025">Marie Bashir Institute for Infectious Diseases and Biosecurity, the University of Sydney, Sydney, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Marie Bashir Institute for Infectious Diseases and Biosecurity, the University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rashid, H" sort="Rashid, H" uniqKey="Rashid H" first="H." last="Rashid">H. Rashid</name><affiliation wicri:level="1"><nlm:aff id="aff0005">National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children's Hospital at Westmead, Westmead, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0015">Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, Sydney, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Discipline of Paediatrics and Child Health, Sydney Medical School, The University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff0025">Marie Bashir Institute for Infectious Diseases and Biosecurity, the University of Sydney, Sydney, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Marie Bashir Institute for Infectious Diseases and Biosecurity, the University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author></analytic><series><title level="j">Paediatric Respiratory Reviews</title><idno type="ISSN">1526-0542</idno><idno type="eISSN">1526-0550</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (therapy)</term><term>Coronavirus Infections (virology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Respiratory Tract Diseases (diagnosis)</term><term>Respiratory Tract Diseases (therapy)</term><term>Respiratory Tract Diseases (virology)</term><term>Travel</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus ()</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (virologie)</term><term>Maladies de l'appareil respiratoire ()</term><term>Maladies de l'appareil respiratoire (diagnostic)</term><term>Maladies de l'appareil respiratoire (virologie)</term><term>Mâle</term><term>Voyage</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Diseases</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Diseases</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Maladies de l'appareil respiratoire</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Travel</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus</term><term>Maladies de l'appareil respiratoire</term><term>Mâle</term><term>Voyage</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) that causes a severe lower respiratory tract infection in humans is now considered a pandemic threat to the Gulf region. Since its discovery in 2012, MERS-CoV has reached 23 countries affecting about 1100 people, including a dozen children, and claiming over 400 lives. Compared to SARS (severe acute respiratory syndrome), MERS-CoV appears to kill more people (40% versus 10%), more quickly, and is especially more severe in those with pre-existing medical conditions. Most MERS-CoV cases (>85%) reported thus far have a history of residence in, or travel to the Middle East. The current epidemiology is characterised by slow and sustained transmission with occasional sparks. The dromedary camel is the intermediate host of MERS-CoV, but the transmission cycle is not fully understood. In this current review, we have briefly summarised the latest information on the epidemiology, clinical features, diagnosis, treatment and prevention of MERS-CoV especially highlighting the knowledge gaps in its transmission dynamics, diagnosis and preventive strategy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A" uniqKey="Zaki A">A. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T" uniqKey="Bestebroer T">T. Bestebroer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berry, M" uniqKey="Berry M">M. Berry</name></author><author><name sortKey="Gamieldien, J" uniqKey="Gamieldien J">J. Gamieldien</name></author><author><name sortKey="Fielding, B C" uniqKey="Fielding B">B.C. 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Corman</name></author><author><name sortKey="Jores, J" uniqKey="Jores J">J. Jores</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li></country><region><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Banik, G R" sort="Banik, G R" uniqKey="Banik G" first="G. R." last="Banik">G. R. Banik</name></noRegion><name sortKey="Banik, G R" sort="Banik, G R" uniqKey="Banik G" first="G. R." last="Banik">G. R. Banik</name><name sortKey="Khandaker, G" sort="Khandaker, G" uniqKey="Khandaker G" first="G." last="Khandaker">G. Khandaker</name><name sortKey="Khandaker, G" sort="Khandaker, G" uniqKey="Khandaker G" first="G." last="Khandaker">G. Khandaker</name><name sortKey="Khandaker, G" sort="Khandaker, G" uniqKey="Khandaker G" first="G." last="Khandaker">G. Khandaker</name><name sortKey="Khandaker, G" sort="Khandaker, G" uniqKey="Khandaker G" first="G." last="Khandaker">G. Khandaker</name><name sortKey="Rashid, H" sort="Rashid, H" uniqKey="Rashid H" first="H." last="Rashid">H. Rashid</name><name sortKey="Rashid, H" sort="Rashid, H" uniqKey="Rashid H" first="H." last="Rashid">H. Rashid</name><name sortKey="Rashid, H" sort="Rashid, H" uniqKey="Rashid H" first="H." last="Rashid">H. Rashid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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